Meropenem

Inyandikorugero:Infobox drug/title
Names
Trade names	Merrem, others
	IUPAC name (4R,5S,6S)-3-(((3S,5S)-5-(Dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;
Clinical data
Drug class	Antibiotic (carbapenem)
Main uses	Meningitis, intra-abdominal infection, pneumonia, sepsis, anthrax
Side effects	Nausea, diarrhea, constipation, headache, rash, pain at site of injection
WHO AWaRe	Script error: No such module "WDfetch".
Pregnancy; category	Inyandikorugero:Infobox drug/pregnancy category
Routes of; use	Intravenous
Defined daily dose	3 gram
External links
AHFS/Drugs.com	Inyandikorugero:Drugs.com
Legal
[[Regulation of therapeutic goods \|Inyandikorugero:Engvar data]]	Inyandikorugero:Infobox drug/licence
Legal status	Inyandikorugero:Infobox drug/legal status
Pharmacokinetics
Bioavailability	100%
Protein binding	Approximately 2%
Elimination half-life	1 hour
Excretion	Kidney
Identifiers
CAS Number	Inyandikorugero:Infobox drug/formatCASnumber; Inyandikorugero:Infobox drug/formatCASnumber;
PubChem CID	Inyandikorugero:Infobox drug/formatPubChemCID; Inyandikorugero:Infobox drug/formatPubChemCID;
PubChem SID	Inyandikorugero:Infobox drug/formatPubChemSID; Inyandikorugero:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Inyandikorugero:Infobox drug/formatIUPHARBPS; Inyandikorugero:Infobox drug/formatIUPHARBPS;
DrugBank	Inyandikorugero:Infobox drug/formatDrugBank; Inyandikorugero:Infobox drug/formatDrugBank;
ChemSpider	Inyandikorugero:Infobox drug/formatChemSpider; Inyandikorugero:Infobox drug/formatChemSpider;
UNII	Inyandikorugero:Infobox drug/formatUNII; Inyandikorugero:Infobox drug/formatUNII;
KEGG	Inyandikorugero:Infobox drug/formatKEGG; Inyandikorugero:Infobox drug/formatKEGG;
ChEBI	Inyandikorugero:Infobox drug/formatChEBI; Inyandikorugero:Infobox drug/formatChEBI;
ChEMBL	Inyandikorugero:Infobox drug/formatChEMBL; Inyandikorugero:Infobox drug/formatChEMBL;
NIAID ChemDB	Inyandikorugero:Infobox drug/formatChemDBNIAID; Inyandikorugero:Infobox drug/formatChemDBNIAID;
PDB ligand	Inyandikorugero:Infobox drug/formatPDBligand; Inyandikorugero:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Inyandikorugero:Infobox drug/formatCompTox; Inyandikorugero:Infobox drug/formatCompTox;
ATC code	Inyandikorugero:Infobox drug/formatATC; Inyandikorugero:Infobox drug/formatATC;
Chemical and physical data
Formula	Inyandikorugero:Infobox drug/chemical formula
Molar mass	Inyandikorugero:Chem molar mass
3D model (JSmol)	Inyandikorugero:Infobox drug/formatJmol; Inyandikorugero:Infobox drug/formatJmol;
	SMILES O=C3N2\C(=C(\S[C@H]1C[C@@H](C(=O)N(C)C)NC1)[C@H](C)[C@@H]2[C@H]3[C@H](O)C)C(=O)O;
	InChI InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1Inyandikorugero:Stdinchicite; Key:DMJNNHOOLUXYBV-PQTSNVLCSA-NInyandikorugero:Stdinchicite;
	Inyandikorugero:Ubl

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Meropenem, igurishwa ku izina rya Merrem mu zindi, ni antibiyotike yagutse. ikoreshwa mu kuvura indwara zitandukanye za bagiteri.^[1] Bimwe muribi birimo meningite, kwandura munda, umusonga, sepsis, na anthrax . Itangwa no gutera inshinge.^[1]

Ingaruka zikunze kugaragara zirimo isesemi, impiswi, impatwe, kubabara umutwe, guhubuka, no kubabara aho batewe inshinge. Ingaruka zikomeye zirimo kwandura <i id="mwJQ">Clostridium diffile</i>, gufatwa, hamwe na allergique harimo na anaphylaxis.^[1] Abafite allergic kubindi β-lactam antibiotique barashobora kuba allergique kuri meropenem.^[1] Gukoresha mugutwita bigaragara ko ari umutekano.^[1] Ari mumuryango wa karbapenem yimiti.^[1] Ubusanzwe Meropenem itera urupfu rwa bagiteri binyuze mu guhagarika ubushobozi bwabo bwo gukora urukuta.^[1] Irwanya cyane gusenyuka na β-lactamase itanga bagiteri.^[1]

Meropenem yahawe patenti mu 1983.^[3] Byemejwe gukoreshwa mu buvuzi muri Amerika mu 1996. Ari kurutonde rwumuryango wubuzima ku isi urutonde rw'imiti yingenzi.^[4] Igiciro cyo kugurisha byinshi mubihugu bikiri mu nzira y'amajyambere kiri hagati ya 3.44 na 20.58 USD kuri garama imwe ya garama guhera muri Mu Bwongereza aya mafaranga agura NHS hafi £ 16 muri 2015.^[5]

Reba

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 "Meropenem". The American Society of Health-System Pharmacists. Archived from the original on 20 January 2011. Retrieved 8 December 2017. Inyandikorugero:Webarchive
↑ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 November 2020. Retrieved 12 September 2020. Inyandikorugero:Webarchive
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in Icyongereza). John Wiley & Sons. p. 497. ISBN 9783527607495. Archived from the original on 2020-09-17. Retrieved 2017-12-09.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 379. ISBN 9780857111562.

[AHFS2017-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 "Meropenem". The American Society of Health-System Pharmacists. Archived from the original on 20 January 2011. Retrieved 8 December 2017. Inyandikorugero:Webarchive

[who-2] "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 November 2020. Retrieved 12 September 2020. Inyandikorugero:Webarchive

[3] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in Icyongereza). John Wiley & Sons. p. 497. ISBN 9783527607495. Archived from the original on 2020-09-17. Retrieved 2017-12-09.

[WHO21st-4] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[BNF69-5] British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 379. ISBN 9780857111562.

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