Meropenem

Meropenem
Amazina
Trade names	Merrem, others
	Izina rya IUPAC (4R,5S,6S)-3-(((3S,5S)-5-(Dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;
Clinical data
Drug class	Antibiotic (carbapenem)
Main uses	Meningitis, intra-abdominal infection, pneumonia, sepsis, anthrax
Side effects	Nausea, diarrhea, constipation, headache, rash, pain at site of injection
WHO AWaRe	Script error: No such module "WDfetch".
Pregnancy; category	AU: B2;
Routes of; use	Intravenous
Defined daily dose	3 gram
External links
AHFS/Drugs.com	Monograph
Legal
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetics
Bioavailability	100%
Protein binding	Approximately 2%
Elimination half-life	Isaha 1
Excretion	Kidney
Chemical and physical data
Formula	C17H25N3O5S
Molar mass	38346 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3N2\C(=C(\S[C@H]1C[C@@H](C(=O)N(C)C)NC1)[C@H](C)[C@@H]2[C@H]3[C@H](O)C)C(=O)O;
	InChI InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1 ; Key:DMJNNHOOLUXYBV-PQTSNVLCSA-N ;
	Inyandikorugero:Ubl

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Meropenem, igurishwa ku izina rya Merrem mu zindi, ni antibiyotike yagutse. ikoreshwa mu kuvura indwara zitandukanye za bagiteri.^[1] Bimwe muribi birimo meningite, kwandura munda, umusonga, sepsis, na anthrax . Itangwa no gutera inshinge.^[1]

Ingaruka zikunze kugaragara zirimo isesemi, impiswi, impatwe, kubabara umutwe, guhubuka, no kubabara aho batewe inshinge. Ingaruka zikomeye zirimo kwandura <i id="mwJQ">Clostridium diffile</i>, gufatwa, hamwe na allergique harimo na anaphylaxis.^[1] Abafite allergic kubindi β-lactam antibiotique barashobora kuba allergique kuri meropenem.^[1] Gukoresha mugutwita bigaragara ko ari umutekano.^[1] Ari mumuryango wa karbapenem yimiti.^[1] Ubusanzwe Meropenem itera urupfu rwa bagiteri binyuze mu guhagarika ubushobozi bwabo bwo gukora urukuta.^[1] Irwanya cyane gusenyuka na β-lactamase itanga bagiteri.^[1]

Meropenem yahawe patenti mu 1983.^[3] Byemejwe gukoreshwa mu buvuzi muri Amerika mu 1996. Ari kurutonde rwumuryango wubuzima ku isi urutonde rw'imiti yingenzi.^[4] Igiciro cyo kugurisha byinshi mubihugu bikiri mu nzira y'amajyambere kiri hagati ya 3.44 na 20.58 USD kuri garama imwe ya garama guhera muri Mu Bwongereza aya mafaranga agura NHS hafi £ 16 muri 2015.^[5]

Reba

1 2 3 4 5 6 7 8 9 10 11 "Meropenem". The American Society of Health-System Pharmacists. Archived from the original on 20 January 2011. Retrieved 8 December 2017. Archived 20 Mutarama 2011 at the Wayback Machine
↑ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 November 2020. Retrieved 12 September 2020. Archived 20 Ugushyingo 2020 at the Wayback Machine
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in Icyongereza). John Wiley & Sons. p. 497. ISBN 9783527607495. Archived from the original on 2020-09-17. Retrieved 2017-12-09.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 379. ISBN 9780857111562.

[AHFS2017-1] 1 2 3 4 5 6 7 8 9 10 11 "Meropenem". The American Society of Health-System Pharmacists. Archived from the original on 20 January 2011. Retrieved 8 December 2017. Archived 20 Mutarama 2011 at the Wayback Machine

[who-2] "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 November 2020. Retrieved 12 September 2020. Archived 20 Ugushyingo 2020 at the Wayback Machine

[3] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in Icyongereza). John Wiley & Sons. p. 497. ISBN 9783527607495. Archived from the original on 2020-09-17. Retrieved 2017-12-09.

[WHO21st-4] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[BNF69-5] British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 379. ISBN 9780857111562.

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