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Ibuprofen

Kubijyanye na Wikipedia
Ibuprofen
(R)-ibuprofen
Amazina
PronunciationInyandikorugero:IPAc-en, Inyandikorugero:IPAc-en, Inyandikorugero:Respell
Trade namesAdvil, Motrin, Nurofen, others
Other namesisobutylphenylpropionic acid
  • (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
Clinical data
Drug classNonsteroidal anti-inflammatory drug (NSAID)
Main usesPain, fever, inflammation[1]
Side effectsHeartburn, rash[1]
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Pregnancy
category
  • AU: C[2]
  • D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus[2]
BreastfeedingSafe[3]
Routes of
use		By mouth, rectal, topical, intravenous
Onset of action30 min[4]
Defined daily dose1.2 g (by mouth) or
1.2 g (parenteral) or
1.2 g (rectal) for pain relief[5] and
30 mg (parenteral) for treatment of ischemic heart diseases[6]
External links
AHFS/Drugs.comMonograph
MedlinePlusa682159
Legal
[[Regulation of therapeutic goods |Inyandikorugero:Engvar data]]
Legal status
Pharmacokinetics
Bioavailability80–100% (by mouth),[7] 87% (rectal)
Protein binding98%[8]
MetabolismLiver (CYP2C9)[8]
Metabolitesibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Elimination half-life2–4 h[9]
ExcretionUrine (95%)[8][10]
Chemical and physical data
FormulaC13H18O2
Molar mass206285 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
Density1.03 g/ml g/cm3
Melting point75 to 78 °C (167 to 172 °F)
Boiling point157 °C (315 °F) at 4 mmHg
Solubility in water0.021 mg/mL (20 °C)
  • CC(C)Cc1ccc(cc1)[C@@H](C)C(=O)O
  • InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) checkY
  • Key:HEFNNWSXXWATRW-UHFFFAOYSA-N checkY
Inyandikorugero:Ubl

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Ibuprofen ni imiti yo mu cyiciro cya nonsteroidal anti-inflammatory (NSAID) ikoreshwa mu kuvura ububabare, umuriro, n’ububabare.[1] Ibi birimo imihango ibabaza, migraine, na rubagimpande ya rubagimpande.[1] Irashobora kandi gukoreshwa mugufunga patent ductus arteriosus kumwana utagejeje igihe.[1] Ishobora gukoreshwa biciye mukanwa cyangwa mumitsi.[1] Mubisanzwe itangira gukora mugihe kingana n isha imwe.[1]

Ingaruka zisanzwe zirimo gutwika no guhubuka.[1] Ugereranije nizindi NSAIDs, irashobora kugira ingaruka nke nko kuva amaraso gastrointestinal.[11] Yongera ibyago byo kunanirwa k'umutima, kunanirwa kw'impyiko, no kunanirwa kw'umwijima.[1] Mugihe gito, ntabwo bigaragara ko byongera ibyago byo kurwara umutima ; icyakora, kuri dosiye ndende irashobora.[11] Ibuprofen irashobora kandi kwangiza asima.[11] Nubwo bidasobanutse niba ari umutekano mugihe cyo gutwita hakiri kare,[1] bigaragara ko ari bibi mugihe cyo gutwita nyuma bityo ntibisabwa.[12] Koresha mugihe konsa ari umutekano.[3] Kimwe nizindi NSAIDs, ikora ibuza umusaruro wa prostaglandine kugabanya ibikorwa bya enzyme cyclooxygenase.[1] Ibuprofen nintege nke zo kurwanya inflammatory kurusha izindi NSAIDs.[11]

Ibuprofen yavumbuwe mu 1961 na Stewart Adams muri Boots UK Limited hanyuma ibanza kugurishwa nka Brufen.[13] Iraboneka munsi yizina ryubucuruzi, harimo Nurofen, Inama na Motrin.[1][14] Yashyizwe ku isoko bwa mbere mu 1969 mu Bwongereza no muri Amerika mu 1974.[1][13] Ari kurutonde rwumuryango wubuzima ku isi urutonde rwimiti yingenzi.[15] Iraboneka nkumuti rusange.[1] Igiciro cyinshi mugihugu kiri mu nzira y'amajyambere kiri hagati ya Inyandikorugero:US$ 0.01 na Inyandikorugero:US$ 0.04 kuri dose.[16] Muri Reta zunzubumwe za Amerika, igura amadolari Inyandikorugero:US$ 0.05 kuri dose.[1] Muri 2017, yari imiti ya 28 yandikiwe cyane muri Amerika, hamwe na barenga 24 miriyoni.[17][18]

Reba

[Hindura | hindura inkomoko]
  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 "Ibuprofen". The American Society of Health-System Pharmacists. Archived from the original on 9 September 2017. Retrieved 2016-10-12.
  2. 1 2 Use During Pregnancy and Breastfeeding
  3. 1 2 "Ibuprofen use while Breastfeeding". Drugs.com (in Icyongereza). Archived from the original on 17 April 2021. Retrieved 29 March 2021.
  4. ↑ "ibuprofen". Archived from the original on 13 January 2015. Retrieved 31 January 2015.
  5. ↑ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 17 October 2020. Retrieved 22 September 2020. Cite error: Invalid parameter "name"who"" in <ref> tag. The supported parameters are: dir, follow, group, name.
  6. ↑ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 November 2020. Retrieved 22 September 2020.
  7. ↑ Davanzo, R; Bua, J; Paloni, G; Facchina, G (November 2014). "Breastfeeding and migraine drugs". European Journal of Clinical Pharmacology (Review). 70 (11): 1313–24. doi:10.1007/s00228-014-1748-0. PMID 25217187.
  8. 1 2 3 Davies, NM (February 1998). "Clinical pharmacokinetics of ibuprofen: The first 30 years". Clinical Pharmacokinetics. 34 (2): 101–54. doi:10.2165/00003088-199834020-00002. PMID 9515184.
  9. ↑ Grosser, T; Ricciotti, E; FitzGerald, GA (August 2017). "The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs". Trends in Pharmacological Sciences (Review). 38 (8): 733–48. doi:10.1016/j.tips.2017.05.008. PMC 5676556. PMID 28651847.
  10. ↑ "Brufen Tablets And Syrup" (PDF). Therapeutic Goods Administration. 31 July 2012. Archived from the original on 20 August 2016. Retrieved 8 May 2014.
  11. 1 2 3 4 British National Formulary, March 2014–September 2014 (2014 ed.). London: British Medical Association. 2014. pp. 686–688. ISBN 978-0857110862.
  12. ↑ "Ibuprofen Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 9 September 2017. Retrieved 22 May 2016.
  13. 1 2 Halford, GM; Lordkipanidzé, M; Watson, SP (2012). "50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams". Platelets. 23 (6): 415–22. doi:10.3109/09537104.2011.632032. PMID 22098129.
  14. ↑ "Chemistry in your cupboard | Nurofen". Archived from the original on 5 June 2014.
  15. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  16. ↑ "Ibuprofen". Archived from the original on 13 February 2021. Retrieved 12 January 2016.
  17. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  18. ↑ "Ibuprofen - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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