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Furosemide

Kubijyanye na Wikipedia
Furosemide
Amazina
PronunciationInyandikorugero:IPAc-en
Other namesFrusemide
  • 4-Chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
Clinical data
Main usesEdema[1]
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Pregnancy
category
  • AU: C
Routes of
use		By mouth, IV, IM
Onset of action30 to 60 min (PO), 5 min (IV)[1]
Defined daily dose40 mg[2]
External links
AHFS/Drugs.comMonograph
Legal
[[Regulation of therapeutic goods |Inyandikorugero:Engvar data]]
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetics
Bioavailability43–69%
MetabolismLiver and kidney glucuronidation
Elimination half-lifeup to 100 minutes
Excretionrenal 66%, biliary 33%
Chemical and physical data
FormulaC12H11ClN2O5S
Molar mass33074 g·mol−1
3D model (JSmol)
  • o1cccc1CNc(cc2Cl)c(C(=O)O)cc2S(=O)(=O)N
  • InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) checkY
  • Key:ZZUFCTLCJUWOSV-UHFFFAOYSA-N checkY
Inyandikorugero:Ubl

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Furosemide, igurishwa ku izina rya Lasix mu zindi, ni imiti ikoreshwa mu kuvura amazi bitewe no kunanirwa ku umutima, inkovu z'umutima , cyangwa indwara z'impyiko.[1] Irashobora kandi gukoreshwa mukuvura umuvuduko ukabije wamaraso.[1] Irashobora gufatwa no guterwa ku imitsi cyangwa mumunwa.[1] Iyo ifashwe kumunwa, mubisanzwe itangira gukora mugihe cyisaha imwe, mugihe imitsi, itangira gukora muminota itanu.[1]

Ingaruka zisanzwe zirimo kumva urumuri ruhagaze, kuvuza amatwi, no kumva urumuri.[1] Ingaruka zikomeye zishobora kuba zirimo electrolyte idasanzwe, umuvuduko ukabije w'amaraso, no kutumva neza.[1] Kwipimisha amaraso birasabwa buri gihe kubavura.[1] Furosemide ni ubwoko bwa loop diuretic ikora mukugabanya reabsorption ya sodium nimpyiko.[1]

Furosemide yahawe patenti mu 1959 kandi yemererwa gukoreshwa mu 1964.[3] Ari kurutonde rw'umuryango wubuzima ku isi urutonde rwimiti yingenzi.[4] Igiciro cyinshi mugihugu kiri mu nzira y'amajyambere kiri hagati ya $ 0.004 na US $ 0.02 kumunsi.[5] Muri Amerika, iraboneka nk'imiti rusange kandi igura amadorari y'Amerika 0.15 kumunsi.[1] Muri 2017, yari imiti ya 17 ikunze kwandikirwa muri Amerika, hamwe na miliyoni zirenga 30 zandikiwe.[6][7] Ari kurutonde rw’ibiro bishinzwe kurwanya ibiyobyabwenge ku isi kubera impungenge z’uko ishobora guhisha ibiyobyabwenge.[8] Yarakoreshejwe kandi mu mafarashi yo gusiganwa mu kuvura no gukumira amaraso ava mu bihaha.[9][10]

Reba

[Hindura | hindura inkomoko]
  1. 1 2 3 4 5 6 7 8 9 10 11 "Furosemide". The American Society of Health-System Pharmacists. Archived from the original on 2015-11-19. Retrieved October 23, 2015.
  2. ↑ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 19 August 2020. Retrieved 30 August 2020.
  3. ↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in Icyongereza). John Wiley & Sons. p. 458. ISBN 9783527607495. Archived from the original on 2019-03-01. Retrieved 2019-03-01.
  4. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. ↑ "Furosemide". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 24 October 2015.
  6. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  7. ↑ "Furosemide - Drug Usage Statistics". ClinCalc. 1 December 1981. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
  8. ↑ "THE 2014 PROHIBITED LIST INTERNATIONAL STANDARD" (PDF). 2014. p. 5. Archived (PDF) from the original on 15 January 2016. Retrieved 24 October 2015.
  9. ↑ Sullivan, S; Hinchcliff, K (April 2015). "Update on exercise-induced pulmonary hemorrhage". The Veterinary Clinics of North America. Equine Practice. 31 (1): 187–98. doi:10.1016/j.cveq.2014.11.011. PMID 25770069.
  10. ↑ Hinchcliff, KW; Couetil, LL; Knight, PK; Morley, PS; Robinson, NE; Sweeney, CR; van Erck, E (2015). "Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement". Journal of Veterinary Internal Medicine. 29 (3): 743–58. doi:10.1111/jvim.12593. PMC 4895427. PMID 25996660.
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